They may not have an appetite, lose weight, and have regular diarrhea. People with macrocytic anemia may also experience digestive issues. nails that are brittle and easily broken.People may not notice symptoms at first, but they can gradually get worse over time. People experiencing a high MCH caused by macrocytic anemia may experience symptoms that follow a particular pattern. taking too many medications containing estrogen.High MCH scores may also be the result of the following: This condition occurs when the blood cells are too big, which can be a result of not having enough vitamin B12 or folic acid in the body. High MCH scores are commonly a sign of macrocytic anemia.
